Metastatic Breast Cancer: Tamoxifen citrate is effective in the treatment of metastatic breast cancer in women and men. In premenopausal women with metastatic breast cancer, tamoxifen citrate is an alternative to oophorectomy or ovarian irradiation. Available evidence indicates that patients whose tumors are estrogen receptor positive are more likely to benefit from tamoxifen citrate therapy. Adjuvant Treatment of Breast Cancer: Tamoxifen citrate is indicated for the treatment of node-positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation. In some tamoxifen citrate adjuvant studies, most of the benefit to date has been in the subgroup with four or more positive axillary nodes.


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Nausea, hot flashes, weight gain or headache may occur. If these effects persist or worsen, notify your doctor promptly. Report promptly abnormal vaginal bleeding or irregular periods, vaginal discharge, groin pain or vision changes. Unlikely but report promptly vomiting or rash. Very unlikely but report promptly dark urine or yellowing eyes and skin, easy bruising, persistent sore throat, fever, mental/mood changes, trouble breathing, unusual tiredness, leg pain or swelling. If you notice other effects not listed above, contact your doctor or pharmacist.

Take NOLVADEX by mouth exactly as prescribed for the full treatment period.

Tell your doctor your medical history, especially of eye problems, blood disorders, cancers, liver disease or any allergies. Use reliable birth control (e.g., proven barrier methods) during treatment and for at least two months after treatment. Consult your doctor or pharmacist. NOLVADEX is not recommended for use during pregnancy. Consult your doctor before using NOLVADEX. It is not known if NOLVADEX is excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using NOLVADEX is not recommended. Consult your doctor before breast-feeding.

Keep all doctor and lab visits because it is important you have your progress monitored.

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include shakiness and dizziness.

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.