EFFEXOR-XR Uses

Effexor-XR is used to treat depression and anxiety disorders. This medicine may be used for other conditions as determined by your doctor.

EFFEXOR-XR General Information

Treats Depression. Venlafaxine (VEN) is a representative of a new class of antidepressants (SNRIs) which inhibit selectively the uptake of serotonin and noradrenaline, but--in contrast to tricyclics--show no affinity for neurotransmitter receptors. Effexor is prescribed for the treatment of depression--that is, a continuing depression that interferes with daily functioning. The symptoms usually include changes in appetite, sleep habits, and mind/body coordination, decreased sex drive, increased fatigue, feelings of guilt or worthlessness, difficulty concentrating, slowed thinking, and suicidal thoughts. Effexor is also prescribed to relieve abnormal anxiety (generalized anxiety disorder). This problem is marked by persistent anxiety for a period of at least 6 months, accompanied by at least 3 of these 6 symptoms: restlessness, fatigue, poor concentration, irritability, muscle tension, and sleep disturbances.

How EFFEXOR-XR Works

This medicine inhibits the return of two chemicals (serotonin and norephinephrine) back into nerve cells. This helps to restore balance of these chemicals which in turn helps to improve mood and relieve depression.

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Buy Effexor XR

nausea, vomiting, loss of appetite changes in sexual function dry mouth constipation nervousness dizziness, drowsiness trouble sleeping

Use caution operating machinery or engaging in activities requiring alertness. If you notice other effects not listed above, contact your doctor or pharmacist.

Each capsule should be swallowed whole with water and not divided, crushed or placed in water. Take this medicine with food either in the morning or evening about the same time every day.

During the first few days your doctor may gradually increase your dose to allow your body to adjust to the medication. Take EFFEXOR with food. Do not take this more often or increase your dose without consulting your doctor. Your condition will not improve any faster but the risk of serious side effects will be increased. Do not stop taking EFFEXOR suddenly without your doctor's approval. Your dose may need to be gradually reduced to prevent adverse effects.

EFFEXOR-XR Storage

Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep this medication in the container it came in, tightly closed, and out of reach of children. Throw away any medication that is outdated or no longer needed.

This medicine should NOT be taken with alcohol. Don’t stop taking this medicine until you have consulted with your doctor first. Stopping this medicine abruptly can cause agitation, dizziness, nausea and fatigue. Patients who have been taking this medicine for 6 weeks or more should taper down their dose over a 2 week period. Before driving or performing other tasks that require your full attention, it is important you know how you react to this medicine.

WARNINGS

Potential for Interaction with Monoamine Oxidase Inhibitors

Adverse reactions, some of which were serious, have been reported in patients who have recently been discontinued from a monoamine oxidase inhibitor (MAOI) and started on venlafaxine, or who have recently had venlafaxine therapy discontinued prior to initiation of an MAOI. These reactions have included

tremor,
myoclonus,
diaphoresis,
nausea,
vomiting,
flushing,
dizziness,
hyperthermia with features resembling neuroleptic malignant syndrome, seizures,
death.

In patients receiving antidepressants with pharmacological properties similar to venlafaxine in combination with an MAOI, there have also been reports of serious, sometimes fatal, reactions.
For a selective serotonin reuptake inhibitor, these reactions have included hyperthermia,

rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, mental status changes that include extreme agitation progressing to delirium and coma.

Some cases presented with features resembling neuroleptic malignant syndrome. Severe hyperthermia and seizures, sometimes fatal, have been reported in association with the combined use of tricyclic antidepressants and MAOIs. These reactions have also been reported in patients who have recently discontinued these drugs and have been started on an MAOI. The effects of combined use of venlafaxine and MAOIs have not been evaluated in humans or animals.

Therefore, because venlafaxine is an inhibitor of both norepinephrine and serotonin reuptake, it is recommended that Effexor XR (venlafaxine hydrochloride) extended-release capsules not be used in combination with an MAOI, or within at least 14 days of discontinuing treatment with an MAOI. Based on the half-life of venlafaxine, at least 7 days should be allowed after stopping venlafaxine before starting an MAOI.

Patients taking MAO inhibitors should not be take this medicine. Do not take St. John’s Wort with this medicine.

If you are or plan on becoming pregnant, talk with your doctor about the benefits vs. the risks while taking this medicine. For nursing mothers, it is unknown whether this medicine is excreted in breast milk. Talk to your doctor if you are or plan to breast feed.

For emergencies, seek medical attention immediately. For non emergencies, contact your local or regional poison control center.

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.

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