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1-AD (1-Androstenediol) Description:
In Pursuit Of The Holy Grail!
You are about to be introduced to the future of prohormones. It is called 1-AD, and it is without a doubt the single most amazing prohormone to be synthesized and sold as a nutritional supplement.
Let’s start by setting something straight. We are not amateurs to the prohormone industry. On the contrary, we actually started the whole prohormone industry. But not only that, we are also responsible for practically every significant innovation in prohormone technology to date. The leader of ErgoPharm, organic chemist Patrick Arnold, was the person who discovered androstenedione and introduced it to the market in 1996. Patrick also discovered and patented Androdiol (4-androstenediol) and Norandrodiol (19-nor-4-androstenediol), and introduced cyclodextrin technology to the prohormone industry.
For the past 18 months Patrick has been feverishly working — almost exclusively — on one project. While scores of less knowledgeable people in the industry periodically made occasional lame, foul ball attempts at finding the “latest, greatest” prohormone, Patrick kept quiet and worked on the development of what essentially could be called the “holy grail” of prohormones.
Patrick wanted this prohormone to have all the attributes most critical to the perfect prohormone. It had to be:
Completely Non-Aromatizable to Estrogens
After months of scouring every book and journal he could locate, including those in foreign languages (i.e. German), Patrick discovered a compound that seemed to be the perfect candidate. That was the easy part. It then took Patrick almost one whole year to figure out how to manufacture the compound cheaply enough for sale as a supplement. Patrick’s lab took on the appearance of ground zero at Hiroshima as he endlessly did reaction after reaction in pursuit of the perfect manufacturing recipe.
Before we introduce exactly what 1-AD is, we want to mention one quick thing. In this industry it is often hard to find straight answers to exactly what something is, and how something works. Most often, the case is that the company is evasive with the facts because there really is no existing science that validates the claims they are making. Either that or they simply do not understand the science themselves. Occasionally a company does have science to back up their products, but they decide that the consumer is too simple minded to appreciate the facts.
ErgoPharm is different. We produce products that are backed up by hard scientific fact, and we take great pride in laying everything on the table.
We understand that not everyone buying our products has a chemistry or biology degree, but we do know that people appreciate being treated with respect and honesty. They want to know they are being told the straight story, even if they don’t have the background to understand every facet of the presentation.
It’s time to introduce what Patrick refers to as “the crown achievement” of his career. The formal chemical name of the compound Patrick developed is 1-androstene-3beta, 17beta-diol. We nicknamed this compound “1-AD” which is a shortened acronym of its chemical name.
This compound is truly unique amongst other prohormones in a variety of ways. Let’s look specifically at 1-AD and what it does.
The Power of 1-Testosterone
You probably are familiar with the “Andro” prohormones, and the “Norandro” prohormones. The former convert to testosterone and the latter to 19-nortestosterone. 1-AD, however, does not fit into either of those categories. That is because 1-AD converts to a relatively unheard of hormone called 1-testosterone. 1-testosterone is what is known as a “double bond isomer” of testosterone.
Although chemically the only difference between testosterone and 1-testosterone is the position of the double bond, pharmacologically the two products are quite different. According to research done by the pharmaceutical giant G.D. Searle and published in the 1960s, 1-testosterone is over 7 times as myotrophic (anabolic) as testosterone(1). That makes 1-testosterone a phenomenally potent compound, surpassing even most synthetic anabolic steroids.
1-testosterone differs from testosterone in another way as well. Being a 5alpha-reduced androgen (a DHT derivative) it simply cannot aromatize to estrogens. The same goes for 1-AD itself — no estrogen transformation can occur. This makes 1-AD unique compared to other prohormones — all of which can either aromatize directly, convert to a product that aromatizes, or both. So what does this mean in the real world? It means that your chances of getting gynecomastia (bitch tits) from 1-AD is essentially zero, and that water retention side effects are vastly reduced compared to other prohormones.
The Only Truly “Orally Active” Prohormone
Natural androgenic steroids are normally not very active orally. Large amounts have to be taken orally to see biological effects. This is because the first pass through the liver causes a massive deactivation of the compounds, primarily through the oxidation of the 17beta-hydroxyl to a 17-keto group. Chemists long ago found that by adding an alkyl (methyl or ethyl) chemical group to the alpha position of the 17 carbon, this oxidation can be prevented. However, this alkyl derivatization also greatly increases the liver toxicity. Therefore the usage of such synthetically altered compounds (methyltestosterone, oxymetholone, stanozolol) are not without substantial risk.
Luckily, there are other ways to render a steroid orally active, and do so without making the compound toxic to the liver. Certain structural modifications can alter the metabolism of steroids making them resistant to liver breakdown. One of these modifications is unsaturation (presence of a double bond) in the 1-position. One steroid that has this structural modification and is orally active is the anabolic steroid Methenolone, also known as Primobolan.
As you may have noticed, this double bond position that makes Primobolan orally active is the same one found in 1-AD, which, by the way, is also orally active. Steroids with this particular double bond characteristic are known as 1-dehydroandrostanes.
During the 60’s and 70’s some papers were published describing the phenomenon of oral activity seen with 1-dehydroandrostanes, including 1-testosterone and 1-AD. What was discovered was that these compounds resist metabolic deactivation by profoundly shifting what is known as the “17-keto redox potential” towards the formation of active 17beta-hydroxyl steroids(2,3). What does this mean? It means that when you take 1-AD, the liver serves primarily to activate the compound, rather than break it down and excrete it as it does with other prohormones and testosterone. It means that 1-AD is “orally active,” yet it does not impart the liver toxicity that 17alpha-alkylation does.
A Natural Hormone Made in the Body
One of the beautiful things about 1-AD is that in addition to its impressive pharmacological activity, it is also a natural androgen made in the human body(4) . This means that it is not foreign to your body, and that it can legally and openly be sold as a nutritional supplement. Furthermore, 1-AD’s high rate of active conversion after oral administration is not just a “theory” of ErgoPharm’s – it has been demonstrated and published in a highly reputable peer reviewed journal.
Let’s put it all together and see what 1-AD has to offer:
High oral activity
Conversion to a hormone 700% more potent than testosterone
Absolutely NO aromatization to estrogens
Natural and safe
There can be no argument that this is the ultimate prohormone. Believe us, there simply are no natural compounds out there that can come close to what 1-AD does, so don’t even bother looking.
1.Counsel et al., “Anabolic Agents. Derivatives of 5alpha-Androst-1-ene”, J. Org. Chem., 27 (1962), 248-251 2. Galletti and Gardi, “Metabolism of 1-Dehydroandrostanes in Man”, J Steroid Biochem, 3 (1972), 933-936 3. Langecker, “Beziehungen Zwischen Substitution im Ring A und Abbau im Stoffwechsel bei Verwandten des Testosterons”, Acta Endocrin, 41 (1962), 494-506 4. Lieberman et al., J. Biol. Chem, 182 (1950), 299 5. Galletti and Gardi, “Metabolism of 1-Dehydroandrostanes in Man”, J Steroid Biochem, 3 (1972), 933-936
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side effects of 1 ad1-AD (1-Androstenediol) Container:
Container Size: 60 Capsules
Serving Size: 1 Capsule
Servings Per Container: 60
Container Size: 180 Capsules
Serving Size: 1 Capsule
Servings Per Container: 180
results of 1 ad1-AD (1-Androstenediol) Ingredients:
Amount Per Serving:
1-androstene-3beta, 17beta-diol: 100 mg
Gelatin, microcrystalline cellulose, modified cornstarch, magnesium stearate, silica.
transdermal 1 ad1-AD (1-Androstenediol) Directions:
For oral use only. As a dietary supplement, take 1 to 3 capsules 3 times daily with food. Do not break open capsules. Do not exceed 3 capsules per day.
1 ad and liver or prostate problems1-AD (1-Androstenediol) Warnings:
Not for use by individuals under the age of 21 years. Do not use if pregnant or nursing. Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.
Allergy Alert: On rare occasions, 1-AD may cause minor skin irritation in some individuals. If this happens please discontinue use.
Note: Use of this product may be banned by some athletic or government associations (including military). Athletes and others should consult their sanctioning organization before use.